Effect of treatment of bronchial asthma of IgE level in children

ABSTRACT

Thirty six children [age ranged between 1.5-11 years] were selected from those presented with bronchial asthma at the paediatric outpatient Clinic of Ain Shams University Hospital. Twenty healthy children with comparable age and sex were added as control group. Twelve patients were treated with corticosteroids, 12 with aminophylline and 12 with terbutaline sulphate. Patients were examined investigated twice [during the attack and 3 weeks after treatment]. Both patients and controls were subjected to estimation of total serum IgE by ELISA technique and determination of absolute eosinophilic count. Results showed significant elevation of IgE level and eosinophilic count of the patients. After cortiosteroid therapy a significant decrease in IgE and eosinophilic count was observed. It was concluded that estimation of serum IgE and absolute eosinophilic count could be used to monitor the response to corticosteroids in patients with bronchial asthma