Relation between cyclosporin circulated level in serum and hepato-renal toxicity in kidney-transplanted patients

ABSTRACT

Blood samples of kidney -transplanted patients were collected and divided into five groups according to their cyclosporin circulated level in serum [less than 50 up to more than 200 ng/ml].Biochemical parameters of hepato-renal function were carried out. Also, cyclosporin level in serum was determined using RIA method. Our results revealed that there is a close relationship between the circulated level of cyclosporin in serum and hepatorenal function. A signs of toxicity was observed in patients with cyclosprin level over 200 ng/ml