effect of high ceiling diuretic [lasix] on the periodontium of albino rats

ABSTRACT

This study was designed to investigate the effect of high dose of furosemide on the periodontium of albino rats. The animals received an intramascular injection equal to 1.6 ml of the ampul of furosemide [represents 80 mg of the drug] day after day for 8 weeks. The rats were sacrificed by cervical dislocation 2,4,6,8,10,12,14 and 16 weeks from the beginning of the experiment. The histopathological results revealed severe degenerative and destructive changes in the gingival tissues and the periodontal ligament as well as apparant bone resorption at the 8th week of the experiment, while cementum was more resistant to resorption than bone. However, such changes were only temporary and reversible