Platelet function and diabetes mellitus

ABSTRACT

Platelet aggregation was found to be enhanced in diabetic patients, who did not show any clinical evidence of diabetic vascular disease. This increase was shown with all the four aggregating agents, that is, ADP, epinephrine, collagen and arachidonic acid. Platelet aggregation was enhanced in diabetic patients with clinically apparent diabetic vascular disease. We did not find any difference between the Platelet aggregation of diabetic patients with and without diabetic vascular complications. The aggregation pattern was found to be similar in all the diabetic groups with all four aggregating agents. No significant difference was found between intensity of aggregation, rate of aggregation and lag phase when different concentrations of the aggregating agents were used