Predictive value of hyperinsulinaemia in subjects with and without coronary heart disease

ABSTRACT

To determine the predictive value of hyperinsulinaemia and associated other cardiovascular risk factors, this study was carried out on two groups of subjects aged between 40 and 65 years, group I [20 subjects with CHD] and group II [20 subjects without CHD]. All cases were subjected to determination of body mass index, ECG, fasting blood glucose and uric acid, complete lipid metabolism parameters and fasting serum insulin concentration by RIA. More than 80% of group I have significant raised levels of serum fasting insulin [30 +/- 15.32 uU/ml]. cholesterol, LDL cholesterol and triglycerides, while low level of HDL Obesity and raised BP [160/95] was more prevalent in group I. From prevalences and sensitivity percentage of these risk factors, we concluded that, hyperinsulinaemia [i.e insulin resistance] is the major predictive risk factor for increased incidence of CHD, the best of lipid parameters is HDL cholesterol and the poorest is triglyceride value, while other different risk factors are of variable importance