Drug-excipients physicochemical in compatibility studies involving temazepam, medazepam and lorazepam
Alexandria Journal of Pharmaceutical Sciences. 1992; 6 (2): 117-120
en Inglés
| IMEMR
| ID: emr-22841
ABSTRACT
Differential scanning calorimetry [DSC] was mainly employed to predict the physicochemical incompatibility of 3 benzodiazepines, viz. temazepam, medazepam and lorazepam, with some common pharmaceutical excipients. The 3 drugs were found to be compatible with Avicel, Ac- Di-Sol, lactose, HPMC, dibasic calcium phosphate, starch, PVP and magnesium stearate. However, interactions of the benzodiazepines with PEG and stearic acid were detected and well confirmed utilizing TLC technique in addition to DSC
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Temazepam
/
Farmacocinética
/
Lorazepam
/
Medazepam
Idioma:
Inglés
Revista:
Alex. J. Pharm. Sci.
Año:
1992
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