In-vivo and in-vitro evaluation of marketed and formulated ketoprofen suppositories

ABSTRACT

The plasma levels for ketoprofen were evaluated following the administration of 3 marketed [A, B and C] and one formulated 100 mg ketoprofen suppositories to 4 healthy male volunteers in a cross over manner. The pharmacokinetic parameters including AUC, Cmax, Tmax, abs. t1/2 and elimination t1/2 were calculated. Using the AUC, the percent bioavailability was calculated relative to that of an oral ketoprofen capsule administered to the same subjects. It was found to be 69.4, 69.0, 91.7 and 77.5 for the br and s A, B, C and for the formulated one, respectively. The dissolution rate was also investigated using the non-membrane method of BP 88 dissolution apparatus. The study revealed that in vivo results were in accordance with the in vitro data