Effect of indomethacin on some parenchymatous organs in rats

ABSTRACT

The effect of indomethacin on some parenchymatous organs of rats was microscopically studied. It was shown that many organs were affected following the therapeutic doses of indomethacin after 14 days of administration. The lungs showed congestion and haemorrhagic areas with thickening of the interstitial septa. The liver showed cellular infiltration and congested portal vessels, sinusoids and central veins, together with cloudy swellings of the hepatocytes and focal necrosis. Specimens of the kidney showed areas of interstitial hameorrhage and nephritis with focal areas of necrosis. Examination of lymph nodes revealed marked hyperplasia together with polymorphic cellular infiltration