Naloxone as an antidote for benzodiazepine: an experimental and clinical study
Egyptian Journal of Psychiatry [The]. 1992; 15 (1): 53-65
en Inglés
| IMEMR
| ID: emr-23559
ABSTRACT
This study evaluates the potential antidote action of naloxone on experimentally induced diazepam and flunitrazepam [benzodiazepines] intoxication in dogs. Its antidote effects is also evaluated in a clinical sample of 8 patients suffering from flunitrazepam intoxication. The clinical findings were suggestive of an antagonistic action of naloxone in flunitrazepam intoxication. It was also found that flunitrazepam exhibits a different pharmacological profile from other members of the benzodiazepine group. Our findings of a selective naloxane-flunitrazepam reversal need to be explained in relation to the mechanism of action of this benzodiazepine, as well as to the equated naloxane-opiates reversal
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Suicidio
/
Ansiolíticos
/
Benzodiazepinas
/
Trastornos Relacionados con Sustancias
/
Diazepam
/
Flunitrazepam
Idioma:
Inglés
Revista:
Egypt. J. Psychiatry
Año:
1992
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