toxicity of the insecticide propetamphos in mice

ABSTRACT

The toxicity of the organophosphorus insecticide propetampos-labelled with C[14] [PTP] was studied in swiss mice. The toxicological studies carried out included the effect of [PTP] on three enzymes namely Choilnesterase SGOT and SGPT. The three doses were 4,8,12 mg/kg used. Samples of RBC and brain, tissue were taken at different time intervals, following intraperitonial [ip] injection of the insecticide. Effect on plasma enzymes was noticed with the highest dose [12 mg/kg], while in RBC an inhibition of the cholinesterase activity was found to increase with increase of dose reaching its maximum the highest dose. On brain cholinesterase the three doses showed a continuous increase in the relative inhibition with the increase of time reaching its maximum value after 48 h. The effect of the three different doses of [PTP] on SGOT and SGPT activities, at different time intervals, was recorded at 24 h intervals, using 8 and 12 mg/kg [PTP] concentration, insignificant effect when applying 4 mg/kg PTP doses