Effect of alloxan-induced diabetes on serum electrolytes and lipids in rabbits

Effect of alloxan on serum glucose, electrolytes and lipids was observed in 20 induced-diabetic rabbits. Thirteen days after alloxan administration sufficient hyperglycemia was detected and the serum levels of magnesium and sodium were lower significantly. Out of 20, eight Rabbits [40%] developed marked hypomagnesemia and hyponatremia which were inversely associated with the degree of hyperglycemia. Serum HDL-cholesterol was also decreased and triglycerides increased statistically. However, the difference in the mean values of total cholesterol, calcium and potassium were found to be non-significant after alloxan injection