Ocytogenetic analysts of two multidrugs resistant cancer cells

ABSTRACT

A detailed cytogenetic investigation was carried out on two sensitive and resistant cell lines, the human chronic myelogenous Ieukemia [k562] and the human burkitt lymphoma [DAUDI]. These cell lines have shown numerous clonal karyotypic alterations. However, numerical alteration was the more common [most notably chromosome gain]. The resistant sublines-R have shown chromosomal rearrangement unique to the resistant sublines. The k562-R subline was characterized by the presence of homogenous staining region [HSR] located at the long arm of chromosome no. 7 while the DAUD1-R was characterized by the presence of double minute chromosomes [DMs]