Some observations on golucosylated hemoglobin in chronic renal failure and the influence of hemodialysis

Glucosylated Hb is a model of non enzymatic postsynthetic protein modification proportionate with blood glucose level. Its role in uremia is however unclear. Moreover, the effect of uremia on Hb glucosylation was shown to be more complicated. Therefore, the aim of this study was to clarify the reflection of uremia on glucosylated Hb level. The material of this study included 30 patients with CRF and CRF diabetics besides 5 non uremic diabetics and 10 healthy controls. Glucosylated Hb was assayed in all subjects and was reported after in uremic cases. We concluded that the level of glucosylated Hb has been significantly reduced in CRF which could be due to shortened red cell survival while in CRF diabetics it was higher due to their high blood glucose. More over, hemodialysis resulted in elevation of glucosylated Hb due to the proved red cell survival. A positive correlation has been revealed between glucosylated Hb and serum creatinne, a finding that may aid in diagnosis and follow up of CRF particularly in doubtful cases