Complement and neutrophil chemotaxis in some dermatophytic infections

ABSTRACT

In this study assessment complement and neutrophil functions were done for 45 cases and 10 healthy controls to evaluate the capacity of different dermatophytes to activate complement and stimulate neutrophil chemotaxis and to detect the results of the interaction of the serum and neutrophil with the fungus. We found that dermatophytes can activate complement and stimulate neutrophil chemotaxis. We could suggest the complement activation a resulting influx of polymorpho leukocytes may stop fungal invasion and the close adherence of neutrophil to fungal hyphae although no sufficient to kill hyphae probably damage the hyphal cell wall and inhibits growth. Also, defective neutrophil chemotaxis motaxis which was found in patients with chronic dermatophytosis was not found to be due to deficiency complement components, this defect could be corrected by Prompt antifungal therapy as the fungal products could alter neutrophil functions. Correction of the associated conditions [e.g. diabetes mellitus].Trials of levamisole, cimetidine ascorbic acids in conjunction with the antifungal therapy in the treatment of the chronic dermatophytosis patients