Immunological evaluation of loratadine in patients with nasal allergy

ABSTRACT

Sixty two patients with allergic rhinitis to Dermatophagoides farinae were selected. Thirty two cases received loratadine 10mg daily and 30 received a placebo. Clinical and immunological assessment were done and done before at the end of the study by skin tests and human basophile degranulation test [HBDT]. A significant clinical improvement was noted in patients receiving loratadine together with significant decrease in skin test response to the allergen and inhibition of degranulation in the HBDT. These results indicate that besides its antihistamine action, loratadine, loratadine has potent antiallergic and antianaphylactic effects