Correlation between fibronectin levels and the severity of pregnancy induced hypertension

ABSTRACT

Plasma levels of fibronectin were measured in 25 primigravidae with pregnancy induced hypertension [PIH] [study group] and in 25 primigravidae with uncomplicated pregnancy [control group] between 30 - 38 weeks gestation. The results indicate that the maternal plasma fibronectin levels increase significantly [p<0.001] from normotensive control women to mild PIH and from mild to severe PIH. It is concluded that measurements of plasma fibronectin might be of importance in the diagnosis, control, and classification of PIH and offer a biochemical marker of this disorder as the blood pressure is significantly correlated with the fibronectin concentration