possible role of the metalloenzyme superoxide dismutase in children suffering from glucose-6-phosphate dehydrogenase deficiency

ABSTRACT

The copper and zinc levels in erythrocytes and serum were measured in 20 children of glucose-6-phosphate dehydrogenase [G6PD] deficiency, and in 10 apparently health subjects used as a control group. Concomitantly hematological values and serum enzyme activities were recorded. The concentration of hemoglobin [Hb], G6PD, superoxide dismutase [SOD], packed cell volume [PCV], mean corpuscular hemoglobin [MCHC] and reticulocytic count [RC] were performed to all the studied subjects. The results revealed that G6PD deficient children have statistical significant lower values of Hb%, PCV, MCHC, Zn in RBC and in serum and lower activity of G6PD. While, statistical significant increase of Cu in RBC, as well as, in serum was recorded. The activity of the enzyme SOD was higher in G6PD deficient children than in normal ones. SOD enzyme protects the cell from the deleterious effect of superoxide free radical [O2]. Correction of hypozincemia in G6PD deficient patients keeps the enzyme more stable and active in performing its function