Clinical versus biochemical and radiological data in assessing activity of vitamin D deficiency rickets

ABSTRACT

The present work included the study of three groups of rachitic children and a control group of ten healthy children. The number of cases in the rachitic groups was 20, 20 and 23 and they were studied one month, after the first, second and third mega dose of vitamin D respectively. Clinical manifestations in the form of broadening of the distal ends of both forearm and leg bones with positive Marfan's sign, persisted after complete biochemical and radiological healing. Deformities mainly in the form of bow legs and occasionally knees persisted after complete biochemical and radiological healing. These findings point to the possible harmful effect of administration of vitamin D on clinical ground only to rachitic infants