Effect of noristerat on the development of the retina of the chick embryo

The present work was concerned with the development of the retina of the chick embryo and the effect of noristerat on its development, aiming for the explanation of the possible hazards of the drug which may occur to the fetus, if the pregnant mother is under the treatment with this drug. Morphological and histological studies were done on the retina of 10, 12 and 14-day old chick embryo treated on the 6th day of incubation by a dose of noristerat equivalent to the average human therapeutic dose [0.2 mg/embryo]. Retardation of growth of the retina was observed in all treated embryos as evidenced by reduction of the size of the retina, associated with disappearance of some layers of the retina