Liver biopsy in hypothyroidism: histopathological and histochemical study

ABSTRACT

Liver biopsies were done in 10 healthy volunteers and 10 hypothyroid patients. Histopathological examination with H and E stain and glycogen content with Best's carmine were determined. Succinic dehydrogenase, alkaline phosphatase, acid phophatase and alpha esterase activities were also evaluated. Increased hepatocyte glycogen content and decrease in both succinic dehydrogenase and acid phosphatase activities were found in hypothyroidism. The significance of these changes were discussed