Hypoglycaemic potentials of withania coagulants and zizyphus sativa

ABSTRACT

Hypoglycaemic activity of two plant species was investigated in normal rabbits and diabetic patients. No hypoglycemic activity was found in aqueous extract of Withania coagulans, while its ethanolic extract showed significant results [P<.05] after 24 hours of drug intake. Maximum reduction [35 and 31% respectively] in blood glucose level was found in diabetic patients after 4 hours of drug ingestion. Zizyphus sativa chloroform extract produced a highly significant [P<.01] glucose lowering effects as compared to its ethanolic extract [P<.01]. The animals loaded with glucose and the two test drugs showed a highly significant result [P<.01] within a time period of 1 to 2 and a half hours post drug administration