Clinical and experimental study of beta 2 selectivity of some beta adrenergic drugs

ABSTRACT

Beta2 agonists are the most widely prescribed antiasthmatic medications. However data of their wanted and unwanted effects are scarce. The cardiovascular and metabolic effects on serum potassium and free fatty acids level of salbutamol, hexaprenaline and fenetrol were studied in 45 ashmatic children. Experimentlly; equipotent doses of the three drugs had been tried on isolated frog's heart and then challenged with increasing doses of propranolol. In this study both clinical and experimental data showed that beta2 agonist under study have a substantial beta2 effects and fenetrol has more cardiovascular and metabolic adverse effects than salbutamol and hexaprenaline; So fenetrol may be less selective for beta2 receptors