Plasma amino acids pattern in portal hypertensive patients with different surgical management techniques

ABSTRACT

Fifty individuals were subjected for determination of plasma amino-acids profile, presented in 3 groups, control group 10 healthy persons, portal hypertensive non complicated group 10 patients, and operative portal hypertension group, included 30 patients where splenectomy were done [10 patient] splenectomy with devascularization [Hassab] was choosen for 10 patients and shunt operation [Warren] was performed for another 10 patients. Heparinized venous blood samples were collected and plasma separated for determination of amino-acids by amino-acid analyzer. Our results revealed non significant variations in amino-acids profile in non complicated portal hypertensive patients, operative with only splenectomy, and Hassab operation groups [P > 0.05], except significant increase [P < 0.01] of aspartic in non operative portal hypertensive and splenectomy groups, than control, and highly significant increase [P < 0.001] of threonine in non operative portal hypertensive and splenectomy with devascularization, this may be due to excess release from peripheral muscle. While amino-acid levels in patients for whom warren's shunt were done showed significant elevation in aspartic, glutamic phenylanine, tyrosine and lysine levels [P < 0.01] and highly significant increase [P < 0.001] in threonine level. This concerning with depriving the liver of portal blood leading to diminish amino-acids metabolism