Synthesis of 6-cyano-7- [P-methoxyphenyl] -5-oxo-2- [polyhydroxyalkyl] -8H- [1,2,4] triazolopyrimidines
Alexandria Journal of Pharmaceutical Sciences. 1993; 7 (3): 171-173
en Inglés
| IMEMR
| ID: emr-26925
ABSTRACT
A series of the hydrazones III, IX and XII were prepared by the reaction of 5-cyano-2-hydrazino-6-[p-methoxyphenyl]- 3,4-dihydropyrimidin-4-one [I] with the respective sugar. Acetylation of the products with acetic anhydride in pyridine was studied. Cyclodehydrogenation of III gave 6-cyano-7-[p- methoxyphenyl]-5-oxo-2-[polyhydroxyalkyl]-8H-[1,2,4] triazolo [1,5-a] pyrimidine [V]. Periodate oxidation of IIIa gave 5-cyano-6-[p- methoxyphenyl]-2-[2-oxoethylidenehydrazino]-3,4-dihydropyrimidin-4- one [VII]
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Índice:
IMEMR (Mediterraneo Oriental)
Asunto principal:
Farmacología
Idioma:
Inglés
Revista:
Alex. J. Pharm. Sci.
Año:
1993
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