interrelationships between dieldrin, intestinal active transport and mucosal cyclic AMP concentrations

ABSTRACT

The effect of dieldrin on the intestinal transport of actively transported non-electrolytes and intestinal mucosal cyclic AMP concentrations was evaluated in the isolated rat jejunum and ileum. Certain dose and concentration levels of dieldrin were found to be capable for enhancing the intestinal active transport of D-glucose and L-leucine. This enhancement in the active transport of non-electrolytes by dieldrin was paralled by an increase in the mucosal cyclic AMP concentrations in both preparations. There was a positive correlation between mucosal cyclic AMP concentrations and the active transport of D-glucose and L-leucine in the isolated jejunum and ileum of rat as indication by investigating the effect of dieldrin in combiution with either forskolin or 3-isobutyl-l-methy-Lxanthine [IBMX]. on these parameters. It is suggested that cyclic AMP may act as a mediator for the enhancement effect of dieldrin on the intestinal active transport of non-electrolytes