effect of the simultaneous use of acetylsalicylic acid and propranolol on dogs with experimentally induced hypertension

The effect of aspirin on the antihypertensive effect of propranolol was investigated. Experimental renal hypertension was induced by bilateral partial ligation of the renal arteries. Propranolol was given either alone into one group of animals or combined with aspirin into other group. The mean BP, heart rate, blood electrolytes, urea and creatinine were determined. Aspirin could obtund the antihypertensive effect of propranolol. The possible mechanisms for these were discussed. It can be concluded that propranolol may act through stimulation of prostaglandin synthesis therefore, its effect could be attenuated by co-administration of aspirin