Effect of chlorpropamide and glibenclamide on plasma electrolytes and kidney functions of diabetic patients

ABSTRACT

The effect of a short term therapy with two sulphonurea hypoglycaemic drugs [Chlorpropamide and Gilbenclamide] on plasma electrolytes [Na[+], K[+], C1[-] and P[-3]], plasma osmolality [P[osm]] glomerular filteration rate [GFR] and kidney excretory functions of 30 patients with recently discovered diabetes mellitus was studied. Results revealed a decrease of P[osm,] glomerular filteration rate, urine excretion rate, Na[+], C1[-], P[-3] reabsorption rate by the kidney in case of chlorpropamide therapy. Glibenclamide produced a diuretic action manifested as an increase of free water clearance [C[H2O]] osmolal clearance C[osm] and plasma osmolality. A decrease of plasma inorganic phosphate, and phosphate reabsorption by the kidney due to a direct tubular action was also recorded, the explanation of these changes was mentioned