Spectroscopic studies on pyrazine carboxylic acid and 2-aminopyridine-carboxylic acid

ABSTRACT

Since early studies [1] the field of pyrazine chemistry had received little attention. When advances in chemotherapy suggested new application for the less accessible substances, renewed interest in the pyrazine derivatives became evident. Pyrazines are aromatic compounds as well as tertiary amines, and their properties resemble those of the pyridines [2] The pyrazine nucleus may be considered as a resonance hybrid of which two of the contributing forms [1] and [2] are analogous to those of benzene. The high electronegativity of the nitrogen atom probably leads to significant additional contributions of from [3] which may have a definite influence on both the basic and aromatic properties of the pyrazines