New synthesis and reactions of 4-benzoylphthalazin-1 [2H] -one

ABSTRACT

As a part of a programme directed towards the synthesis of aroyl pyridazines which are precursors of some fused pyridazine derivatives, Ismail et al.[1,2] reported recently a novel method for the synthesis of 4-aroylpyridazin-3[2H] ones [3]. This investigation deals with applying this method to the synthesis of 4-benzoylphthalazin-l [2H]-one [1] which was first prepared in poor yield as a product of the rearrangement of 4-benzoylphthalazine[4] Now we would like to report a simple convenient method for the synthesis of 4-benzoyl-phthalazin -1 [2H]-one [1] which involves the oxidation of 4-benzylphthalazin-l[2H]-one [2] by sodium dichromate in acetic acid