comparative study of the effects of salicylates and diclofenac sodium [voltaren] on renal functions of rheumatic patients

ABSTRACT

The present study was done on 20 patients with Rheumatoid arthritis who gave a negative history of renal disease and were normotensive. Ten patients received salicylates in the form of Aspirin while the others received, diclofenac sodium, which is a new non-steroidal antirheumatic agent. Serum creatinine concentration, creatinine clearance, sodium and potassium in serum and urine, osmotic pressure of serum and urine were measured before and after medication. Salicylates apparently affect renal function in patients with Rheumatoid arthritis while diclofenac sodium is a quite safe drug