Early detection of pregnancy following ovulation induction and intra-uterine insemination in luteal phase defect infertile patients

ABSTRACT

Ovarian stimulation and intra-uterine insemination were induced in patients with luteal phase defect [LPD]. The corpus luteum function was supported by human chorionic gonadotropin. The early pregnancy was detected 14 days after insemination. The concentration of progestrone and beta-HCG was significantly higher in the luteal support group than the non-luteal support group. The concentration of luteinizing hormone, prolactin and estradiol was significantly higher in the pregnant group compared to non-pregnant group. The pregnancy rate in the support group was also significantly higher than the non-support group [64% versus 36% respectively]. The early detection of pregnancy in severe LPD patients followed with luteal support therapy was found in this study to have clinical significance in pregnancy maintenance