controlled lectin affinity cytochemical study of sialoconjugates in laryngeal squamous cell carcinoma during immunomodulatory therapy with S2-complex

ABSTRACT

The sialoconjugates of squamous cell caresnoma of the larynx treated successfully with immunotherapy by S2- complex were studied. The terminal oligosaccharides of glycoconjugates of the membranes of malignant cells were investigated using soybean agglutinin as a lectin probe and a histochemical reaction for sialic acid. Post- treatment changes included unmasking of galactose and N- acetylgalactoseamine residues of glycoconjugates as a result of loss of sialosyl residues from cell surface glycoconjugates. The loss of sialic acid residues profoundly influences the malignant behaviour of tumour cells. The results of the study may turn to be one of the fundamental aspects by which S2- complex produces its effects