Characterization of reed-sternberg cells with granulocyte specific monoclonal antibody

ABSTRACT

Monoclonal antibody Leu M[1] represents a highly specific marker to locate granulocyte antigen in Reed-Sternberg cells in Hodgkin's disease. Except the L and H variants of Reed-Sternberg cells in lymphocyte predominance variety in which antigens are probably sialylated. All the cases of non-Hodgkin's lymphoma were negative with this marker, because of absence of antigen. Therefore this specific marker characterizes granulocyte origin of Reed- Sternberg cells