Sustained release of diclofenac sodium form dry adsorbed emulsions

ABSTRACT

Sustained release W/O dry adsorbed emulsions containing diclofenac sodium were prepared. The effect of particle size, different emulsifying agents and various hydrophilic adsorbents on the sustained release characteristics of diclofenac sodium was studied. The drug release from dry adsorbed emulsions prepared with calcium stearate was slower than those prepared with Span 60. The effect of hydrophilic adsorbents on the drug release was found to be in the following order Avical PH 101 > Aerosil 200 > Avicel RC-591. The release kinetics from the prepared particles showed that no one model was able adequately to describe the release situation. In vivo studies using human volunteers revealed a sustained release action up to 18 hours