Preliminary study of the anti diabetic effect of sammo in rats

ABSTRACT

The dried powdered leaves of sammo plant has been used for a long time by some diabetic patients in the sense that it improved their diabetic state In our study, we tested the effect of the leaves of sammo on the blood glucose level, serum bilirubin, serum oxalecetic transaninase [SGOT], serum pyrvic transaminase [SGPT], serum bilirulin and serum ceratinine in non diabetic and alloxanized diabetic rats. Also histopathologicl examination of the pancreas [using modified aldehyde fuchsin stain], liver and kidney [using Hematoxlin and Eosin stain] was performed. Administration of the dried powder leaves of sammo orally, to non diabetic and diabetic rats in a dose of 1.2 gram/kg/day for 30 days produced significant decrease of the fasting serum glucose when the serum glucose was estimated 15 days and 30 days after administration of the dried powdered leaves of sammo Histopathological examination of the pancreas [using modified aldehyde fuchsin stain] of diabetic rats revealed that the dried powdered leaves produced regeneration of the beta cells of the islets of longerhans similarly hyperplasia of beta cells of the islets of langerhans was demonstrated in the non diabetic rats after administration of the dried powdered leaves of the plant. No toxic effect on the liver or kidney was evidence in non diabetic or diabetic rats after oral administration of the dried powdered leaves of the plant 30 days to non diabetic and diabetic rats, evidence by biochemical and histopathological study. Further investigations, including long term toxicity studies are necessary before it is justifiable to use the dried powdered leaves of the plant by the diabetic patiens