Time factor in the effect of reperfusion of the ischemic cardiac muscle on the changes in T wave voltage and area, serum creatine phosphokinase and infarct size

ABSTRACT

The aim of this work was to detect the best time of reperfusion of the ischemic myocardium in rats. Reperfusion started 30 minutes to 180 minutes after induction of ischemia T wave voltage and area SCPK and infarction size [% of left ventricle] were the parameters studied. It was found that although the T wave voltage and area increased significantly after induction of ischemia, yet, they were not indicators of the duration of ischemia SCPK increased significantly in all groups and the infarct size showed no relation to the duration of ischemia Finally, It was clear that myocardial ischemia for the interval between 30 minutes up to 180 minutes cannot be recovered by reperfusion as evidence by persistence of high values of T- wave voltage and area after 30 minutes of reperfusion and the failure of recovery of high SCPK and the infarct size