Gamma irradiation-induced early gastrointestinal disturbances: role of cystamine as a protective agent

ABSTRACT

The effect of the lethal dose [8 Gy] of whole body gamma irradiation on the early gastrointestinal disturbances in rat was investigated in- vivo as well as in-vitro. Results of the in-vivo study revealed that an early, almost immediately, progressive increase in the weight of the stomach contents as well as marked increase in the intestinal motility were detected during the first 6 hours post irradiation. Results of the in-vitro study showed alterations in the spontaneous contractions of the isolated intestine of the rat. The irregular contraction pattern characteristics of jejunal segments isolated from non-irradiated [control] rat was changed to a more regular pattern 1, 3 hours as well as one day after gamma-irradiation. Administration of Cystamine [50 mg/kg] prior to gamma irradiation [8 Gy] produced a good radiaprotective effect and ameliorated the effect of gamma-irradiation on the stomach. Besides, it normalized the disturbed intestinal movements. In conclusion, the present study suggests the application of Cystamine as a promising start for its trial in clinical radiotherapy especially for patients undergoing abdominal radiotherapy