Midazolam for prolonged intravenous sedation in patients with tetanus

ABSTRACT

Midazolam was used for prolonged sedation in ten adult patients with severe tetanus in the Intensive Care Unit for periods ranging from 10 to 50 days. An infusion was started soon after induction and adjusted according to clinical needs. All the patients were intubated and ventilated and in addition received morphine 1-2 mg/hr and alcuronium or pancuronium infusion. Two patients died from complications of tetanus. Six patients recovered from the effects of midazolam within 24 hrs of the cessation of infusion. Recovery took 48 and 72 hrs respectively in the other two patients. Midazolam is a suitable drug for long-term sedation in patients with tetanus. However, dose requirements are variable and recovery may be delayed in some patients