Can D-penicillamine be used in treatment of acute paracetamol hepatotoxicity?

ABSTRACT

Forty mature albino rats were divided equally into three test groups and on control group. Paracetamal was given rally [1000 mg/kgm] to rats of the three test groups. D-penicillamine was given intrapevtoneally [0.5 mg/gm] one hour and 15 minutes afer the toxic para cetamol dose to rats of the second and third groups respictively. Statistical analysis of values of serum ALT, AST and bilirubin showed high significant elevation in the first group; significant decrease in the second group and drametic significant inprovement in the third group. All biochemical results coincided completely and confirmed by the histopathological findings in the livers of the studied rats