Effect of concurrent administration of acetaminophen with acetyl salicylic acid or indomethacin on the kidney, liver and stomach of rats

ABSTRACT

This study was conducted on 72 albino rats weighing averagely 100- 120 g. Theywere divided into 6 equal groups, the first group was served as control, the2nd, 3rd, 4th, 5th, 6th groups were given acetyl salicylic acid, indomethacin,acetaminophen, acetyl salicylic acid + acetaminophen and indomethacin +acetaminophen, respectively. Drugs were given orally in dose of 1/10 LD50daily for 30 days. After this period, the animals were subjected tobiochemical investigations [serum urea, creatinine, total bilirubin, ALT, AST]and histopathological studies [kidney, liver and stomach]. It was found thatconcurrent administration of acetaminophen with acetyl salicylic acid orindomethacin had good protection against gastric erosive effect of eitheracetyl salicylic acid or indomethacin, moreover, no exaggeration of thehepatic and renal impairment was detected