Reduced fertility in male albino rats following exposure to environmental pollutant diphenamide

ABSTRACT

Thirty-five male albino rats were divided into two groups. The first group[20 animals] received diphenamide in an oral dose of 70 mg/kg. b. wt. weekly,the rest of animals served as controls. At the end of eight weeks, the animalswere cervically dislocated. Epididymal contents were collected. Spermconcentration, percentage of the head abnormalities as well as sperm motilityand live/dead% were examined. Testis, liver and kidney were collectedfor the histopathological examination. A significant reduction in sperm cellconcentration, sperm motility and live/dead percentage and an increase of headabnormalities were detected. Degenerative changes and necrosis of testis,liver and kidney were recorded