Effect of streptozotocin induced diabetes and administration of insulin on some blood clotting parameters and platelet count in male albino rats

ABSTRACT

The prothrombin time, activated partial thromboplastin time, fibrinogen concentration and platelet count were determined in diabetic and insulin treated diabetic mature male albino rats. The values of prothrombin and activated partial thromboplastin time showed significant [p <0.01] decrease in the diabetic and semidiabetic rats at 10 and 20 days following treatment, fibrinogen concentration increased in diabetic rats, 10 and 20 days post-insulin administration and in the semidiabetic rats after 20 days. Platelet count increased significantly in the diabetic rats treated with 40 U insulin daily after 20 days although the clotting parameters were not affected. The results presented are indicative of coagulation activation in diabetic rats and the periodic administration of insulin will reverse the adverse effects of diabetes