Effect of alpha Adrenergic blocker [phentolamine] on propionylpromazine induced hyperglycemia in rats

ABSTRACT

The present study was conducted on 32 albino rats to investigate the effect of the alpha adrenergic blocker "phentolamine" on the hyperglycemia induced by propionylpromazine. The results revealed that propionylpromazine injection induced significant increase in glucose levels accompanied with significant decrease of insulin levels; phentolamine injection induced hypoglycemia with increased level of insulin than control; injection of phentolamine with propionylpromazine resulted in a significant decrease of glucose level accompanied with increased insulin level alone and completely counteract the propionylpromazine induced hyperglycemia