histological changes in the liver of albino neonate rats born to orally hyperglycaemic mothers

ABSTRACT

This work demonstrated that at birth the offsprings of the hyperglycemic mothers were hyperglycemic too, and this neonatal hyperglycemia gradually declined to reach the normal level by the age of four weeks. This might prove the initial impairment of the function of the exhausted beta cells of the pancreatic islets in these hyperglycemic offsprings and their gradual recovery. On the other hand, the hepatocytes of the rats born to hyperglycemic mothers were markedly affected all over the lobules. At birth, they were enlarged and they showed fatty changes which could be attributed to the fetal hyperglycemic and hyperinsulinemic state induced by the maternal hyperglycemia. No other microscopic changes could be detected. This work also proved that these fetal hepatic fatty changes, due to maternal hyperglycemia were not permanent, where slow recovery of the organ was observed and it was nearly complete by the age of four weeks