Electron microscopy versus light microscopy as a diagnostic and prognostic tool in sclerema

ABSTRACT

Rhinoscleroma is a chronic progressive disease that can be accomplished by both light microscope and electron microscope. 30 cases clinically diagnosed as scleroma and had not received medical treatment before, were diagnosed after biopsy by both light and electron microscopy. The results of electron microscopy were more accurate than that of light microscopy, especially in the atrophic cases. After receiving medication, rebiopsy was done to ensure pathological cure. Some cases which were considered cured by light microscopy proved to have active disease by electron microscopy and continued on medical treatment for longer periods