Synthesis and biological activity of some new 2- [alkyl/ acylthio] -4-methyl and 4,6dimethyloxazolo [4,5-c] quinolines

ABSTRACT

Quinoline and its derivatives are known to exhibit antibacterial and antifungal activities. Oxazoloquinoline compounds possess significant biological activities as bactericidal Gram-positive and Gram-negative agents [1-5]. The antibiotic nybomycin contains the oxazolo [5,4,3,-ij] quinoline nucleus [1,2] and it has been observed that nybomycin acetate and dichloro acetate derivatives are more active than parent nybomycin specially against staphylococci [2]. In view of the above facts it was therefore considered of interest to undertake the synthesis of some new 2-[alkyl/acylthio]-4-methyi and 4,6-dirnethyl-oxazolo [4,5-c] quinolines [IIa, IIb] in order to evaluate their antibacterial and antifungal activities