Cytological effects desferrioxamine in somatic cells of Swiss albino mice

ABSTRACT

Desferroxamine an iron chelator, has been shown to be ineffective in increasing the frequency of micronuclei in bone marrow cells of mice on acute and sub - acute treatment. However, a significant mitodepressive effect is produced at the higher dose on sub - acute treatment. The mito - depressive potentials of DFO may be either due to the disproptionate ratio of Fe2+/Fe3+ which is known to stimulate lipid peroxidation or due to total chelation of iron resulting in bone narrow depression and anemic condition