Treatment of hirsutism in polycystic ovarian syndrome with diane, 50MCG ethinyl estradiol and 2MG cyproterone acetate

The value of Diane in the treatment of hirsutism in polycystic ovarian syndrome was assessed subjectively and objectively in a double blind trial in 20 women studied for one year. The menstrual frequency was recorded. Circulating levels of testosterone, dihydroepiandrosterone sulphate [DHEASO4], FSH, LH and pelvic ultrasonography was done before treatment and after 3, 6 and 12 months of therapy. Significant beneficial effects of the treatment were noted in nearly 70% of the cases. 20% cases required additional therapy and 10% failed to respond. Minimal side effects were observed. Withdrawal bleeding was irregular and scanty with Diane but the levels of LH, testosterone, DHEASO4 and estrogen were decreased to within normal limits with the disappearance of the typical polycystic ovarian picture on ultrasonography