Experimental canine pancreatic allogenic segmental transplantation: the short term role of octreotide in the control of the exocrine secretion problems of the transplant

ABSTRACT

The transverse pancreatic segment was transplanted from donor dogs to alloxan-diabetic recipient dogs determined by leukocyte cross-matching test. Nine transplantations were performed of which 4 dogs received. Octreotide [somatostatin derivative] therapy that gave marked improvement of the survival, local surgical results and diabetes control, in comparison to the other 5 dogs that did not receive the drug. This is attributed to suppression of the exocrine component of the transplanted segment