Formulation and evaluation of chloramphenicol albumin microspores in suppository form

ABSTRACT

Chloramphenicol albumin microspheres containing 25% dextrose as additive were prepared in the form of suppositories. Suppositories were formulated from Witepsol H15, Witepsol E75 and a blend of polyethylene glycols using the fusion method. The in vitro evaluation of chloramphenicol albumin microspheres revealed that microspheres prepared by emulsification method exhibited good results in terms of yield [>89.9%] and drug content [approximately 90%]. The suppositories made with Witepsol H15 showed the highest drug release as compared with the other tested bases. The mechanism of drug release profiles from suppositories containing Witepsol H15 or Witepsol E75 was found to conform the diffusion controlled system, while the suppositories made with polyethylene glycols followed first order release kinetics